About Mutations in the APC Gene

Most APC mutations cause a condition called Familial Adenomatous Polyposis (FAP). FAP increases your risk for certain types of cancers, including colorectal ( ...

APC is classified as a tumor suppressor gene. Tumor suppressor genes prevent the uncontrolled growth of cells that may result in cancerous tumors. The protein ...

2007年10月1日 — The adenomatous polyposis coli (APC) gene is a key tumor suppressor gene. Mutations in the gene have been found not only in most colon ...

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell ...

APC gene mutations are found in about 10 to 15 percent of non-inherited (sporadic) desmoid tumors; these mutations are somatic, which means they are acquired ...

2013年3月1日 — The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes.

The APC gene encodes a multidomain protein that plays a major role in tumor suppression by antagonizing the WNT (see WNT1; 164820) signaling pathway.

由 W Hankey 著作 · 2018 · 被引用 158 次 — The APC gene encodes a 312-kDa protein (Fig. 2) that performs diverse cellular functions and localizes to multiple subcellular compartments. Mutations in APC ...

由 R Fodde 著作 · 2002 · 被引用 578 次 — Mutations in the adenomatous polyposis coli (APC) gene are not only responsible for familial adenomatous polyposis (FAP), but also play a rate-limiting role ...